Cracking the Olfactory Code

 

We are part of a multi-investigator project aimed at achieving the first comprehensive characterization of the mammalian olfactory code, ranging from odorant receptors to odor representations and circuitry in the brain to innate odor-driven behavior. We are developing tools to map responses to large numbers of odors across the olfactory bulb and to link these response patterns to identified odorant receptors and their known response specificity. This project is funded by NSF as part of the BRAIN Initiative, and we collaborate with five other PIs: Sri Kosuri (UCLA), Hiro Matsunami (Duke), Lisa Stowers (Scripps Research Institute), Vladimir Itskov (Penn State) and Marcelo Magnasco (Rockefeller).   

Relevant Publications

Rothermel M, Brunert D, Zabawa C, Díaz-Quesada M, Wachowiak M (2013) Transgene Expression in Target-Defined Neuron Populations Mediated by Retrograde Infection with Adeno-Associated Viral Vectors. The Journal of Neuroscience 33:15195-15206.

Wachowiak M, Economo MN, Díaz-Quesada M, Brunert D, Wesson DW, White JA, Rothermel M (2013) Optical Dissection of Odor Information Processing In Vivo Using GCaMPs Expressed in Specified Cell Types of the Olfactory Bulb. The Journal of Neuroscience 33:5285-5300.

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